Apigenin-7-glucuronide

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$690	Check With Us
200mg	$1035	Check With Us
500mg	$1745	Check With Us

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Cat #: V31029 CAS #: 29741-09-1 Purity ≥ 99%

Description: Apigenin-7-glucuronide is a novel and potent bioactive compound that inhibits Matrix Metalloproteinases (MMP).

References: Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	446.36
Molecular Formula	C21H18O11
CAS No.	29741-09-1
SMILES Code	O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C=C4)OC3=C2)=O
Synonyms	Apigenin 7-glucuronide; Apigenin 7-O-beta-D-glucuronide; Scutellarin A; UNII-2CQ5KB3CH0; Apigenin 7-O-beta-D-glucuronide; Apigenin-7-O-beta-D-glucuronoside;

Protocol	In Vitro	Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2403 mL	11.2017 mL	22.4034 mL	44.8069 mL
5mM	0.4481 mL	2.2403 mL	4.4807 mL	8.9614 mL
10mM	0.2240 mL	1.1202 mL	2.2403 mL	4.4807 mL
20mM	0.1120 mL	0.5601 mL	1.1202 mL	2.2403 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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