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API-1

This product is for research use only, not for human use. We do not sell to patients.

API-1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1950Check With Us
500mg$3250Check With Us
1g$4875Check With Us
email: [email protected]        [email protected]

Cat #: V11457 CAS #: 36707-00-3 Purity ≥ 98%

Description: API-1 (API1) is a novel and potent Akt inhibitor, inducing GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis.

References: Donghwa Kim, et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016 Oct 21;291(43):22856.

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Molecular Weight (MW)337.29
Molecular FormulaC13H15N5O6
CAS No.36707-00-3
SMILES CodeO=C(C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=NC=NC(N)=C3C1=O)N           
SynonymsNSC-177233; API 1; NSC177233; API1; NSC 177233; API-1;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9648 mL14.8240 mL29.6481 mL59.2962 mL
5mM0.5930 mL2.9648 mL5.9296 mL11.8592 mL
10mM0.2965 mL1.4824 mL2.9648 mL5.9296 mL
20mM0.1482 mL0.7412 mL1.4824 mL2.9648 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.