Description: Amrubicin HCl (also known as SM-5887 hydrochloride), a third-generation synthetic 9-amino-anthracycline, is a potent DNA topoisomerase II inhibitor with antineoplastic activity. It can be used for the research of cancer. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. This agent has demonstrated a higher level of anti-tumor activity than conventional anthracycline drugs without exhibiting any indication of the cumulative cardiac toxicity common to this class of compounds. It is marketed in Japan since 2002 by Sumitomo Pharmaceuticals.