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Amino-PEG4-t-butyl ester

This product is for research use only, not for human use. We do not sell to patients.

Amino-PEG4-t-butyl ester
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$380Check With Us
1g$600Check With Us
5g$1520Check With Us

Cat #: V5620 CAS #: 581065-95-4 Purity ≥ 98%

Description: Amino-PEG4-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.

References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Product Promise

Promise
Molecular Weight (MW)321.41
Molecular FormulaC15H31NO6
CAS No.581065-95-4
SMILES CodeO=C(OC(C)(C)C)CCOCCOCCOCCOCCN
SynonymsAmino-PEG4-t-butyl ester
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.1113 mL15.5565 mL31.1129 mL62.2258 mL
5mM0.6223 mL3.1113 mL6.2226 mL12.4452 mL
10mM0.3111 mL1.5556 mL3.1113 mL6.2226 mL
20mM0.1556 mL0.7778 mL1.5556 mL3.1113 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.