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Amino-PEG3-t-butyl ester

This product is for research use only, not for human use. We do not sell to patients.

Amino-PEG3-t-butyl ester
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$400Check With Us
5g$900Check With Us
10g$1350Check With Us

Cat #: V11108 CAS #: 252881-74-6 Purity ≥ 98%

Description: Amino-PEG3-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.

References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Product Promise

Promise
Molecular Weight (MW)277.36
Molecular FormulaC13H27NO5
CAS No.252881-74-6
SMILES CodeO=C(OC(C)(C)C)CCOCCOCCOCC
SynonymsAmino-PEG3-t-butyl este
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.6054 mL18.0271 mL36.0542 mL72.1085 mL
5mM0.7211 mL3.6054 mL7.2108 mL14.4217 mL
10mM0.3605 mL1.8027 mL3.6054 mL7.2108 mL
20mM0.1803 mL0.9014 mL1.8027 mL3.6054 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.