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Amino-PEG3-acid

This product is for research use only, not for human use. We do not sell to patients.

Amino-PEG3-acid
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$500Check With Us
1g$800Check With Us
5g$2025Check With Us
email: [email protected]        [email protected]

Cat #: V11104 CAS #: 784105-33-5 Purity ≥ 98%

Description: Amino-PEG3-acid is a PEG analogue containing an amino group with a terminal carboxylic acid.

References: Kevin HAMBLETT, et al. Anti-her2 biparatopic antibody-drug conjugates and methods of use. WO2019173911A1.

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Molecular Weight (MW)221.25
Molecular FormulaC9H19NO5
CAS No.784105-33-5
SMILES CodeOC(CCOCCOCCOCCN)=O
SynonymsAmino-PEG3-acid
ProtocolIn VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.5198 mL22.5989 mL45.1977 mL90.3955 mL
5mM0.9040 mL4.5198 mL9.0395 mL18.0791 mL
10mM0.4520 mL2.2599 mL4.5198 mL9.0395 mL
20mM0.2260 mL1.1299 mL2.2599 mL4.5198 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.