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AMG-25

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AMG-25
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Cat #: V2155 CAS #: 1003311-62-3 Purity ≥ 98%

Description: AMG-25 (AMG25) is a novel, oral, potent and selective inhibitor of c-Kit with anticancer activity and desirable pharmacokinetic properties. It inhibits c-Kit with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively.

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CAS No.1003311-62-3
SMILES Code O=C1C(C2=CC3=CN=C(N)N=C3C=C2)=C(C)C=CN1C4=CC=C(C5=NC=CO5)C=C4
ProtocolIn Vitroc-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50=>5.0, 40, 7.8 , and >5.0 μM, respectively)[1].
In Vivoc-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats[1]. c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng•h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats[1].
These protocols are for reference only. InvivoChem does not independently validate these methods.
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