AMG-176
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $7020 | To Be Confirmed |
| 200mg | $10530 | To Be Confirmed |
| 500mg | $17765 | To Be Confirmed |
: Cat #: V3448 CAS #: 1883727-34-1 Purity ≥ 98%
Description: AMG-176 (AMG176; tapotoclax) is a novel, potent, selective and orally bioavailable inhibitor of MCL-1 (myeloid cell leukemia-1) with a Ki of 0.13 nM.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 613.21 |
|---|---|
| Molecular Formula | C33H41ClN2O5S |
| CAS No. | 1883727-34-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(N1)C2=CC(N(C[C@H]3[C@@H](CC3)[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S1(=O)=O)C4)=C(C=C2)OC[C@@]54CCCC6=CC(Cl)=CC=C65 |
| Synonyms | tapotoclax; tapotoclaxum; AMG-176; AMG 176; AMG176 |
| Protocol | In Vitro | Tapotoclax is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, Tapotoclax binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6308 mL | 8.1538 mL | 16.3076 mL | 32.6153 mL |
| 5mM | 0.3262 mL | 1.6308 mL | 3.2615 mL | 6.5231 mL |
| 10mM | 0.1631 mL | 0.8154 mL | 1.6308 mL | 3.2615 mL |
| 20mM | 0.0815 mL | 0.4077 mL | 0.8154 mL | 1.6308 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.