Almorexant HCl (ACT 078573)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $990 | Check With Us |
| 250mg | $1550 | Check With Us |
| 500mg | $2325 | Check With Us |
: Cat #: V1308 CAS #: 913358-93-7 Purity ≥ 98%
Description: Almorexant HCl (also known as ACT-078573; ACT078573), the hydrochloride salt of Almorexant, is a novel, potent, orally bioactive, competitive and dual orexin1/2 receptor antagonist indicated for the treatment of sleep disorders/insomnia.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 549.02 |
|---|---|
| Molecular Formula | C29H32ClF3N2O3 |
| CAS No. | 913358-93-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 72 mg/mL (131.1 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 51 mg/mL (92.9 mM) | |
| Solubility In Vivo | 2% DMSO+25% β-cyclodextrin+saline: 9 mg/mL |
| Synonyms | ACT078573 HCl; ACT-078573 HCl; Almorexant HCl; ACT 078573 HCl; |
| Protocol | In Vitro | Almorexant hydrochloride (1 μM) promote tyrosine phosphorylation of SHP2/OX1R complex. Almorexant hydrochloride (1 μM) inhibits the cellular growth of AsPC-1 cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8214 mL | 9.1071 mL | 18.2143 mL | 36.4285 mL |
| 5mM | 0.3643 mL | 1.8214 mL | 3.6429 mL | 7.2857 mL |
| 10mM | 0.1821 mL | 0.9107 mL | 1.8214 mL | 3.6429 mL |
| 20mM | 0.0911 mL | 0.4554 mL | 0.9107 mL | 1.8214 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.