Allitinib tosylate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1145 | Check With Us |
| 250mg | $2000 | Check With Us |
| 500mg | $3000 | Check With Us |
: Cat #: V34046 CAS #: 1050500-29-2 Purity ≥ 99%
Description: Allitinib tosylate (formerly AST-1306; AST1306; AST 1306), the tosylate of Allitinib, is a selective and covalent/irreversible inhibitor of EGFR and ErbB2 with potential anticancer activity.
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| Molecular Weight (MW) | 621.08 |
|---|---|
| Molecular Formula | C31H26ClFN4O5S |
| CAS No. | 1050500-29-2 |
| SMILES Code | C=CC(NC1=CC2=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)N=CN=C2C=C1)=O.OS(=O)(C5=CC=C(C)C=C5)=O |
| Synonyms | Allitinib tosylate; AST1306 TsOH; AST-1306 TsOH; AST 1306 TsOH; ALS1306 TsOH; ALS-1306 TsOH; ALS1306 TsOH; AST 6 TsOH; AST-6 TsOH; AST6 TsOH |
| Protocol | In Vitro | AST1306 tosylate potently inhibits the EGFR T790M/L858R double mutant, exhibiting an IC50 value of 12±2 nmol/L. AST1306 tosylate (0.001-1.0 μM; 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families. AST1306 tosylate (0.1, 0.5, 1.0, 5.0 μM) can dramatically inhibit the growth of both tumor cells on soft agar, and SK-OV-3 cells exhibited much more sensitivity than that of A549 cells. AST1306 tosylate inhibits the activation of tyrosine kinases and downstream signaling pathways in A549 cells, Calu-3 cells and SK-OV-3 cells. AST1306 tosylate dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells. AST1306 tosylate (AST-1306 (TsOH); 0.19-6.25 μM; 72 hours) induces a significant, concentration-dependent inhibition of the growth of HIH3T3-EGFR T790M/L858R cells. |
|---|---|---|
| In Vivo | AST1306 tosylate (AST-1306 (TsOH); p.o.; 25-100 mg/kg; twice daily; for 28 days) causes a dramatic suppression of tumor growth in SK-OV-3 and Calu-3 xenograft models. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6101 mL | 8.0505 mL | 16.1010 mL | 32.2020 mL |
| 5mM | 0.3220 mL | 1.6101 mL | 3.2202 mL | 6.4404 mL |
| 10mM | 0.1610 mL | 0.8050 mL | 1.6101 mL | 3.2202 mL |
| 20mM | 0.0805 mL | 0.4025 mL | 0.8050 mL | 1.6101 mL |
The molarity calculator equation
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The dilution calculator equation
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.