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| Size | Price | Stock |
|---|---|---|
| 2mg | $80 | 3-6 Days |
| 5mg | $100 | 3-6 Days |
| 10mg | $160 | 3-6 Days |
| 25mg | $280 | 3-6 Days |
| 50mg | $430 | 3-6 Days |
| 100mg | $570 | 3-6 Days |
| 250mg | $790 | 3-6 Days |
: Cat #: V0561 CAS #: 897383-62-9 Purity ≥ 99%
Description: Allitinib (formerly also known as AST1306; AST-1306) is a novel, potent, selective and covalent / irreversible inhibitor of EGFR and ErbB2 with potential antitumor activity. With IC50s of 0.5 nM and 3 nM, it inhibits both EGFR and ErbB2. It is also effective against the mutation EGFR T790M/L858R. Compared to other kinases, it is more potent against cells that overexpress ErbB2, and it is 3000-fold more selective for the ErbB family. In both cell-free and cell-based systems, AST-1306 suppresses the enzymatic activities of EGFR and ErbB2, as well as EGFR resistant mutants.
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| Molecular Weight (MW) | 448.88 |
|---|---|
| Molecular Formula | C24H18ClFN4O2 |
| CAS No. | 897383-62-9 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | Allitinib; AST1306; ALS-1306; ALS1306; AST 6; AST-6; AST-1306; Allitinib free base; AST 1306; ALS1306; AST6 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2278 mL | 11.1388 mL | 22.2777 mL | 44.5553 mL |
| 5mM | 0.4456 mL | 2.2278 mL | 4.4555 mL | 8.9111 mL |
| 10mM | 0.2228 mL | 1.1139 mL | 2.2278 mL | 4.4555 mL |
| 20mM | 0.1114 mL | 0.5569 mL | 1.1139 mL | 2.2278 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.