Alfacalcidol-D6

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V32405 CAS #: 1641940-94-4 Purity ≥ 99%

Description: Alfacalcidol-D6 is the deuterated form of Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1-alpha-Hydroxyvitamin D3). Alfacalcidol (1-hydroxycholecalciferol), an active metabolite of Vitamin D, is a potent and non-selective VDR activator medication that has been widely used in the treatment of osteoporosis. Alfacalcidol has been revealed to play a part in bone and mineral homeostasis via binding to the VDR (vitamin D receptor) in calcium-related target organs, such as intestine, bone, kidney and parathyroid gland.

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Molecular Weight (MW)	406.67
Molecular Formula	C₂₇H₃₈D₆O₂
CAS No.	1641940-94-4

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4590 mL	12.2950 mL	24.5900 mL	49.1799 mL
5mM	0.4918 mL	2.4590 mL	4.9180 mL	9.8360 mL
10mM	0.2459 mL	1.2295 mL	2.4590 mL	4.9180 mL
20mM	0.1229 mL	0.6147 mL	1.2295 mL	2.4590 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.