Alexidine Dihydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $400 | Check With Us |
| 1g | $600 | Check With Us |
| 5g | $1510 | Check With Us |
: Cat #: V10758 CAS #: 1715-30-6 Purity ≥ 99%
Description: Alexidine Dihydrochloride is a novel and potent inhibitor of PTPMT1 (Protein Tyrosine Phosphatase Localized to the Mitochondrion 1) with antibacterial and anti-plaque activity.
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| Molecular Weight (MW) | 581.71 |
|---|---|
| Molecular Formula | C26H58Cl2N10 |
| CAS No. | 1715-30-6 |
| SMILES Code | N=C(NC(NCC(CC)CCCC)=N)NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N.Cl.Cl |
| Synonyms | Alexidine Dihydrochloride; Alexidine 2HCl; |
| Protocol | In Vitro | Alexidine dihydrochloride results in 50% killing of HUVECs and lung epithelial cells, at concentrations 5- to 10-fold higher than the MIC required to kill planktonically growing fungal pathogens. Inhibition of planktonic growth by Alexidine dihydrochloride reveals a complete inhibition of filamentation or proliferation of the imaged fungi. Alexidine dihydrochloride is able to decimate at low concentrations (1.5 to 6 μg/mL) mature biofilms of Candida, Cryptococcus, and Aspergillus spp. that are known to be resistant to almost all classes of antifungal drugs. In fact, at 10-fold-lower concentrations (150 ng/mL) of planktonic MICs, Alexidine dihydrochloride could inhibit lateral yeast formation and biofilm dispersal in C. albicans. Alexidine dihydrochloride displays activity against most Candida spp.; MIC values of ≤1.5 μg/mL are observed for all isolates tested under planktonic conditions, with the exception of Candida parapsilosis and Candida krusei. Interestingly, Alexidine dihydrochloride also displays striking activity against clinically relevant fluconazole-resistant Candida isolates: C. albicans (CA2, CA6, and CA10), C. glabrata (CG2 and CG5), C. parapsilosis (CP5), and C. auris (CAU-09 and CAU-03). |
|---|---|---|
| In Vivo | Chosen to focus on biofilm formation by C. albicans, since a murine biofilm model has been well established in this fungus and used for testing the effects of established and new antifungal agents. The effect of the drugs on the 24-h-old biofilms growing in the jugular vein catheters of mice is visualized microscopically, which reveals significantly lower density of the biofilms in catheters treated with Alexidine dihydrochloride. In fact, fungal CFU determination reveals that Alexidine dihydrochloride inhibits 67% of fungal biofilm growth and viability, compared to the control untreated biofilms. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7191 mL | 8.5953 mL | 17.1907 mL | 34.3814 mL |
| 5mM | 0.3438 mL | 1.7191 mL | 3.4381 mL | 6.8763 mL |
| 10mM | 0.1719 mL | 0.8595 mL | 1.7191 mL | 3.4381 mL |
| 20mM | 0.0860 mL | 0.4298 mL | 0.8595 mL | 1.7191 mL |
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
+
%ddH2O
Calculation Results:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.