ALC-0315 | CAS 2036272-55-4

ALC-0315

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1500	Check With Us
500mg	$2500	Check With Us
1g	$3750	Check With Us

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Cat #: V2455 CAS #: 2036272-55-4 Purity ≥ 99%

Description: ALC-0315 (ALC0315; ALC 0315) is a synthetic, colorless oily cationic lipid and an ionizable amino lipid used in combination with other lipids in the formation of lipid nanoparticles (LNPs) as non-viral gene delivery system.

References: Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021;29(3):898-900.

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Molecular Weight (MW)	766.27
Molecular Formula	C48H95NO5
CAS No.	2036272-55-4
SMILES Code	OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O
Synonyms	ALC-0315; ALC 0315; ALC0315;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3050 mL	6.5251 mL	13.0502 mL	26.1005 mL
5mM	0.2610 mL	1.3050 mL	2.6100 mL	5.2201 mL
10mM	0.1305 mL	0.6525 mL	1.3050 mL	2.6100 mL
20mM	0.0653 mL	0.3263 mL	0.6525 mL	1.3050 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.