This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | In Stock |
| 200mg | $675 | In Stock |
| 500mg | $1135 | In Stock |
: Cat #: V2896 CAS #: 256925-03-8 Purity ≥ 98%
Description: AL082D06 (formerly known as D-06), is a nonsteroidal glucocorticoid receptor (GR) antagonist which is characterized by a tri-aryl methane core chemical structure.
References: Miner JN, et al. A nonsteroidal glucocorticoid receptor antagonist. Mol Endocrinol. 2003 Jan;17(1):117-27.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 409.91 |
|---|---|
| Molecular Formula | C23H24ClN3O2 |
| CAS No. | 256925-03-8 |
| Storage | -20℃ for 3 years in powder formrrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 7.5 mg/mLrrr |
| Water: <1 mg/mLrrr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | CN(C)C1=CC=C(C(C2=CC=C(N(C)C)C=C2)C3=CC([N+]([O-])=O)=CC=C3Cl)C=C1 |
| Synonyms | AL-082D06; AL082D06; AL 082D06; D-06; D06; D 06 |
| Protocol | In Vitro | AL 082D06 (D06) binds specifically to GR with nanomolar affinity. Addition of AL 082D06 causes a dose-dependent decrease in transcriptional activation from the MMTV:Luc reporter stimulated with half-maximal DEX concentrations. AL 082D06 acts to antagonize reporter activity using several glucocorticoid-responsive promoter- reporter systems including the 3-kb tyrosine amino transferase (TAT) promoter and less complex promoters comprised of isolated glucocorticoid response element (GRE) sequences. AL 082D06 competes with 3H-Dex for baculovirus-expressed GR with nanomolar affinity. Other intracellular receptors (AR, ER, PR, and MR) have no affinity for AL 082D06 in a similarly structured binding assay with the appropriate receptor and tritiated ligand (>2500 nM). AL 082D06 has no activation efficacy on the progesterone, androgen, mineralocorticoid, retinoid, glucocorticoid, or estrogen receptors. AL 082D06 is very efficacious at antagonizing GR activity but exhibits much weaker efficacy when tested against the other steroid receptors in contrast to the reference antagonists used as controls. |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4396 mL | 12.1978 mL | 24.3956 mL | 48.7912 mL |
| 5mM | 0.4879 mL | 2.4396 mL | 4.8791 mL | 9.7582 mL |
| 10mM | 0.2440 mL | 1.2198 mL | 2.4396 mL | 4.8791 mL |
| 20mM | 0.1220 mL | 0.6099 mL | 1.2198 mL | 2.4396 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.