AKI603

This product is for research use only, not for human use. We do not sell to patients.

AKI603
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$3203-6 Days
10mg$5003-6 Days
25mg$7603-6 Days
50mg$10603-6 Days
100mg$15703-6 Days
email: [email protected]        [email protected]

Cat #: V2332 CAS #: 1432515-73-5 Purity ≥ 99%

Description: AKI603 is an AurorKinase A (AurA) inhibitor (antagonist) with IC50 of 12.3 nM that was developed to overcome the BCR-ABL-T315I resistance mutation in leukemia. AKI603 has potent antiproliferation activity against leukemia cells.

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Molecular Weight (MW)409.445021867752
Molecular FormulaC19H23N9O2
CAS No.1432515-73-5
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsAKI-603; AKI603; AKI 603
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4423 mL12.2117 mL24.4233 mL48.8466 mL
5mM0.4885 mL2.4423 mL4.8847 mL9.7693 mL
10mM0.2442 mL1.2212 mL2.4423 mL4.8847 mL
20mM0.1221 mL0.6106 mL1.2212 mL2.4423 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.