AG1478 HCl (Tyrphostin AG-1478)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $860 | Check With Us |
| 1g | $1420 | Check With Us |
| 5g | $3590 | Check With Us |
: Cat #: V5151 CAS #: 170449-18-0 Purity ≥ 98%
Description: AG-1478 HCl (also known as Tyrphostin AG-1478) is a novel, potent and selective EGFR (epidermal growth factor receptor) inhibitor with IC50 of 3 nM in cell-free assays.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 352.21 |
|---|---|
| Molecular Formula | C16H15Cl2N3O2 |
| CAS No. | 170449-18-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 25 mg/mL (79.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 13 mg/mL (41.2 mM) | |
| Solubility In Vivo | 15% Captisol: 30mg/mL |
| SMILES Code | COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC.[H]Cl |
| Synonyms | Tyrphostin AG-1478; AG1478; AG-1478; AG 1478; Tyrphostin AG 1478; NSC 693255; NSC-693255 |
| Protocol | In Vitro | AG-1478 (AG1478) is irreversible for growth regulation of human lung (A549) and prostate (DU145) cancer cell lines, cultured in chemically defined DMEM/F12 medium. AG-1478 seems to be more effective at lower concentrations, but is unable to completely inhibit growth of A549 cells. |
|---|---|---|
| In Vivo | Administration of AG-1478 (AG1478) significantly reduces myocardial inflammation, fibrosis, apoptosis, and dysfunction in both two obese mouse models. ApoE-/- mice are first fed with HFD for 8 weeks (ApoE-HFD), and then administrated with AG-1478 (10 mg/kg/day) or 542 (10 mg/kg/day) for another 8 weeks by oral gavage. AG-1478 or 542 treatment blocks HFD induced cardiac EGFR phosphorylation in vivo, without affecting the plasma level of low density lipoprotein (LDL) and total triglyceride (TG). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8392 mL | 14.1961 mL | 28.3922 mL | 56.7843 mL |
| 5mM | 0.5678 mL | 2.8392 mL | 5.6784 mL | 11.3569 mL |
| 10mM | 0.2839 mL | 1.4196 mL | 2.8392 mL | 5.6784 mL |
| 20mM | 0.1420 mL | 0.7098 mL | 1.4196 mL | 2.8392 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.