AG126
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $568 | Check With Us |
| 250mg | $965 | Check With Us |
| 500mg | $1445 | Check With Us |
: Cat #: V33675 CAS #: 118409-62-4 Purity ≥ 99%
Description: AG126 is a tyrosine kinase inhibitor which can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2).
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 215.17 |
|---|---|
| Molecular Formula | C10H5N3O3 |
| CAS No. | 118409-62-4 |
| SMILES Code | N#C/C(C#N)=C/C1=CC=C([N+]([O-])=O)C(O)=C1 |
| Synonyms | AG 126; AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile; |
| Protocol | In Vitro | AG126 (10 μM; overnight) increases the viability of ARPE-19 cells. |
|---|---|---|
| In Vivo | AG 126 (intraperitoneal injection; 1-10 mg/kg; 1 h and 6 h after Zymosan treatment) treatment attenuates the degree of multiple organ failure (MOF) associated with Zymosan-induced peritonitis in the rat. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.6475 mL | 23.2374 mL | 46.4749 mL | 92.9498 mL |
| 5mM | 0.9295 mL | 4.6475 mL | 9.2950 mL | 18.5900 mL |
| 10mM | 0.4647 mL | 2.3237 mL | 4.6475 mL | 9.2950 mL |
| 20mM | 0.2324 mL | 1.1619 mL | 2.3237 mL | 4.6475 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.