AG-636
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1500 | Check With Us |
| 250mg | $2600 | Check With Us |
| 500mg | $3900 | Check With Us |
: Cat #: V2473 CAS #: 1623416-31-8 Purity ≥ 99%
Description: AG 636 (AG636; AG-636) is a novel,potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor (IC50=17 nM) which has strong anticancer effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 343.38 |
|---|---|
| Molecular Formula | C21H17N3O2 |
| CAS No. | 1623416-31-8 |
| SMILES Code | O=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O |
| Synonyms | AG-636; AG 636; AG636; |
| Protocol | In Vitro | AG-636 has strong growth-inhibitory activity in cancer cell lines of hematologic versus solid tumor origin. |
|---|---|---|
| In Vivo | AG-636 (10-100 mg/kg ; oral gavage; twice daily; for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9122 mL | 14.5611 mL | 29.1223 mL | 58.2445 mL |
| 5mM | 0.5824 mL | 2.9122 mL | 5.8245 mL | 11.6489 mL |
| 10mM | 0.2912 mL | 1.4561 mL | 2.9122 mL | 5.8245 mL |
| 20mM | 0.1456 mL | 0.7281 mL | 1.4561 mL | 2.9122 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.