AG-494 (Tyrphostin AG-494)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $765 | Check With Us |
| 1g | $1250 | Check With Us |
| 5g | $3160 | Check With Us |
: Cat #: V5152 CAS #: 133550-35-3 Purity ≥ 98%
Description: AG-494 (formerly also known as Tyrphostin AG-494) is a novel and potent inhibitor of epidermal growth factor receptor (EGFR) kinase with an IC50 value of 1 µM in HT-22 cells.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 280.28 |
|---|---|
| Molecular Formula | C16H12N2O3 |
| CAS No. | 133550-35-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(NC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C |
| Synonyms | AG-494; AG 494; AG494; Tyrphostin AG-494 |
| Protocol | In Vitro | n DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5679 mL | 17.8393 mL | 35.6786 mL | 71.3572 mL |
| 5mM | 0.7136 mL | 3.5679 mL | 7.1357 mL | 14.2714 mL |
| 10mM | 0.3568 mL | 1.7839 mL | 3.5679 mL | 7.1357 mL |
| 20mM | 0.1784 mL | 0.8920 mL | 1.7839 mL | 3.5679 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.