Afegostat D-Tartrate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1650 | To Be Confirmed |
| 200mg | $2475 | To Be Confirmed |
| 500mg | $4175 | To Be Confirmed |
: Cat #: V21265 CAS #: 957230-65-8 Purity ≥ 98%
Description: Afegostat D-Tartrate (Isofagomine D-Tartrate, AT2101 D-Tartrate), designed as a pharmacological chaperone, was an experimental drug under investigation for the treatment of certain forms of Gaucher's disease.
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| Molecular Weight (MW) | 297.26 |
|---|---|
| Molecular Formula | C10H19NO9 |
| CAS No. | 957230-65-8 |
| SMILES Code | O[C@@H]1CNC[C@H](CO)[C@H]1O.O=C(O)[C@@H](O)[C@H](O)C(O)=O |
| Synonyms | AT2101; AT-2101, AT 2101; Isofagomine D-Tartrate; Isofagomine; Afegostat; D-Isofagomine; isoFagomine. Plicera; |
| Protocol | In Vitro | Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3641 mL | 16.8203 mL | 33.6406 mL | 67.2812 mL |
| 5mM | 0.6728 mL | 3.3641 mL | 6.7281 mL | 13.4562 mL |
| 10mM | 0.3364 mL | 1.6820 mL | 3.3641 mL | 6.7281 mL |
| 20mM | 0.1682 mL | 0.8410 mL | 1.6820 mL | 3.3641 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.