ADX-47273 (BA 94673139)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | Check With Us |
| 500mg | $1650 | Check With Us |
| 1g | $2480 | Check With Us |
: Cat #: V1087 CAS #: 851881-60-2 Purity ≥ 98%
Description: ADX47273 (ADX-47273; BA-94673139; BA94673139) is a potent, selective and specific mGlu5 positive allosteric modulator(PAM) with important biological activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 369.36 |
|---|---|
| Molecular Formula | C20H17F2N3O2 |
| CAS No. | 851881-60-2 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 74 mg/mL (200.3 mM)rr |
| Water:<1 mg/mLrr | |
| Ethanol: 30 mg/mL (81.2 mM) | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| SMILES Code | O=C(C1=CC=C(F)C=C1)N2C[C@@H](C3=NC(C4=CC=C(F)C=C4)=NO3)CCC2 |
| Synonyms | BA 94673139; ADX-47273; BA-94673139; BA94673139; ADX 47273; ADX47273 |
| Protocol | In Vitro | ADX-47273 (0.1 nM-10 μM; 5 min) causes a concentration-dependent increase in the response to 50 nM glutamate in HEK 293 cells expressing rat mGlu5 without eliciting a response by itself |
|---|---|---|
| In Vivo | ADX47273 (1-10 mg/kg; a single i.p.) dose-dependently increases ERK and CREB phosphorylation in rat hippocampus and prefrontal cortex | |
| Animal model | Male Long-Evans rats | |
| Dosages | 1, 10 mg/kg |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7074 mL | 13.5369 mL | 27.0739 mL | 54.1477 mL |
| 5mM | 0.5415 mL | 2.7074 mL | 5.4148 mL | 10.8295 mL |
| 10mM | 0.2707 mL | 1.3537 mL | 2.7074 mL | 5.4148 mL |
| 20mM | 0.1354 mL | 0.6768 mL | 1.3537 mL | 2.7074 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.