Aderbasib | CAS 791828-58-5

Aderbasib

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
5mg	$360	To Be Confirmed
10mg	$590	To Be Confirmed

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Cat #: V10342 CAS #: 791828-58-5 Purity ≥ 99%

Description: Aderbasib (formerly INCB-7839; INCB007839) is a novel, orally bioactive, and potent sheddase inhibitor with potential anticancer activity. It also inhibits ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins. Aderbasib was being under clinical trials by Incyte as a potential adjunctive treatment for metastatic breast cancer. However, the development was terminated in 2011.

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Molecular Weight (MW)	416.47082
Molecular Formula	C21H28N4O5
CAS No.	791828-58-5
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Synonyms	INCB7839 INCB007839INCB 7839 INCB-007839INCB-7839 INCB 007839

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4011 mL	12.0056 mL	24.0113 mL	48.0226 mL
5mM	0.4802 mL	2.4011 mL	4.8023 mL	9.6045 mL
10mM	0.2401 mL	1.2006 mL	2.4011 mL	4.8023 mL
20mM	0.1201 mL	0.6003 mL	1.2006 mL	2.4011 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.