Adaphostin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $650 | To Be Confirmed |
| 200mg | $975 | To Be Confirmed |
| 500mg | $1645 | To Be Confirmed |
: Cat #: V10305 CAS #: 241127-58-2 Purity ≥ 99%
Description: Adaphostin (NSC-680410) is the adamantyl ester of AG957, acting as a novel and potent activator of Fas-mediated death pathway in Bcr/Abl-positive leukaemia.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 393.48 |
|---|---|
| Molecular Formula | C24H27NO4 |
| CAS No. | 241127-58-2 |
| SMILES Code | O=C(OC12CC3CC(C2)CC(C3)C1)C4=CC=C(NCC5=CC(O)=CC=C5O)C=C4 |
| Synonyms | Adaphostin |
| Protocol | In Vitro | Adaphostin down-regulates p210bcr/abl in K562 cells and inhibits granulocyte colony formation in chronic myelogenous leukemia (CML) specimens at lower concentrations without enhanced toxicity in normal progenitors. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5414 mL | 12.7071 mL | 25.4143 mL | 50.8285 mL |
| 5mM | 0.5083 mL | 2.5414 mL | 5.0829 mL | 10.1657 mL |
| 10mM | 0.2541 mL | 1.2707 mL | 2.5414 mL | 5.0829 mL |
| 20mM | 0.1271 mL | 0.6354 mL | 1.2707 mL | 2.5414 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.