Abiraterone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $450 | Check With Us |
| 10g | $650 | Check With Us |
| 20g | $975 | Check With Us |
: Cat #: V0800 CAS #: 154229-19-3 Purity ≥ 98%
Description: Abiraterone (formerly also known as CB 7598; CB7598; CB-7598; trade name Zytiga) is a novel, higly potent, irreversible and selective CYP17 inhibitor with potential antineoplastic activity.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 349.51 |
|---|---|
| Molecular Formula | C24H31NO |
| CAS No. | 154229-19-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 5 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: 5.4 mg/mL | |
| SMILES Code | O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)C(C5=CC=CN=C5)=CC[C@@]4([H])[C@]3([H])CC=C2C1 |
| Synonyms | Abiraterone; CB 7598; CB7598; CB-7598; US trade name: Zytiga. |
| Protocol | In Vitro | Significant inhibition of proliferation of the AR-positive prostate cancer cell lines LNCaP and VCaP with doses of Abiraterone ≥5 μM is confirmed. |
|---|---|---|
| In Vivo | The 0.5 mmol/kg/d Abiraterone treatment dose is previously shown to yield serum concentrations of about 0.5 to 1 μM. Xenograft tumor growth in the control group is widely variable, with some tumors growing slowly and only a subset of tumors exhibiting robust growth. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8611 mL | 14.3057 mL | 28.6115 mL | 57.2230 mL |
| 5mM | 0.5722 mL | 2.8611 mL | 5.7223 mL | 11.4446 mL |
| 10mM | 0.2861 mL | 1.4306 mL | 2.8611 mL | 5.7223 mL |
| 20mM | 0.1431 mL | 0.7153 mL | 1.4306 mL | 2.8611 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.