Abequolixron (RGX-104) HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1450	Check With Us
500mg	$2080	Check With Us
1g	$3120	Check With Us

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Cat #: V3966 CAS #: 610318-03-1 Purity ≥ 98%

Description: Abequolixron HCl (formerly RGX-104; SB-742881; SB742881), the hydrochloride salt of RGX104, is a novel potent and orally bioavailable liver-X nuclear hormone receptor-beta (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

References: Tavazoie MF, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 Feb 8;172(4):825-840.e18.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	632.54
Molecular Formula	C34H34Cl2F3NO3
CAS No.	610318-03-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 130 mg/mLr
	Water: < 1 mg/mLr
	Ethanol: N/A
SMILES Code	O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4=CC=CC =C4)C)=C1.[H]Cl
Synonyms	SB742881 HCl; RGX-104; RGX104; SB-742881 hydrochloride; SB 742881; RGX-104 free form, RGX 104 hydrochloride

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5809 mL	7.9046 mL	15.8093 mL	31.6186 mL
5mM	0.3162 mL	1.5809 mL	3.1619 mL	6.3237 mL
10mM	0.1581 mL	0.7905 mL	1.5809 mL	3.1619 mL
20mM	0.0790 mL	0.3952 mL	0.7905 mL	1.5809 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.