Abacavir
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $750 | Check With Us |
| 10g | $1200 | Check With Us |
| 20g | $1800 | Check With Us |
: Cat #: V9903 CAS #: 136470-78-5 Purity ≥ 98%
Description: Abacavir (formerly also known as ABC, or 1592U89; trade names: Ziagen; Epzicom) is a commonly used nucleoside analogue of the NRTI class with potent antiviral activity against HIV-1.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 286.34 |
|---|---|
| Molecular Formula | C14H18N6O |
| CAS No. | 136470-78-5 |
| SMILES Code | NC1=NC2=C(N=CN2[C@@H]2C[C@H](CO)C=C2)C(NC2CC2)=N1 |
| Synonyms | Epzicom; ABC, Ziagen |
| Protocol | In Vivo | Abacavir (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promoted thrombus formation |
|---|---|---|
| Animal model | Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J) | |
| Dosages | 2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg | |
| Administration | Intrascrotal or oral administration for 4 h |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4924 mL | 17.4618 mL | 34.9235 mL | 69.8470 mL |
| 5mM | 0.6985 mL | 3.4924 mL | 6.9847 mL | 13.9694 mL |
| 10mM | 0.3492 mL | 1.7462 mL | 3.4924 mL | 6.9847 mL |
| 20mM | 0.1746 mL | 0.8731 mL | 1.7462 mL | 3.4924 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.