A286982
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1400 | Check With Us |
| 500mg | $2050 | Check With Us |
| 1g | $3075 | Check With Us |
: Cat #: V3083 CAS #: 280749-17-9 Purity ≥ 98%
Description: A-286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction with IC50 of 44 nM in an LFA-1/ICAM-1 binding assay.
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| Molecular Weight (MW) | 453.56 |
|---|---|
| Molecular Formula | C24H27N3O4S |
| CAS No. | 280749-17-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| Synonyms | A286982; A 286982 |
| Protocol | In Vitro | A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2048 mL | 11.0239 mL | 22.0478 mL | 44.0956 mL |
| 5mM | 0.4410 mL | 2.2048 mL | 4.4096 mL | 8.8191 mL |
| 10mM | 0.2205 mL | 1.1024 mL | 2.2048 mL | 4.4096 mL |
| 20mM | 0.1102 mL | 0.5512 mL | 1.1024 mL | 2.2048 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.