ɑ-Tocopherolquinone

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$800	Check With Us
1g	$1450	Check With Us
5g	$3670	Check With Us

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Cat #: V13340 CAS #: 7559-04-8 Purity ≥ 98%

Description: ɑ-Tocopherolquinone (Vitamin E Quinone), a vitamin E oxidation product with antioxidant activities, was an investigational drug in phase II clinical trials for the treatment of inherited mitochondrial respiratory chain diseases, however this research has been discontinued.

References: K Shimazaki, et al. Studies on electron transfer systems in the marine diatom Phaeodactylum tricornutum. II. Identification and determination of quinones, cytochromes, and flavins. J Biochem. 1978 Jun;83(6):1639-42.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	446.71
Molecular Formula	C29H50O3
CAS No.	7559-04-8
SMILES Code	O=C(C(C)=C1C)C(C)=C(CCC(C)(O)CCCC(C)CCCC(C)CCCC(C)C)C1=O
Synonyms	A-0001; EPI-A-0001; EPIA-0001; A 0001; EPI A 0001; D-α-Tocopherylquinone, Tocopherylquinone; EPIA 000; A 0001; EPI A 0001; EPIA 0001; Vitamin E Quinone (D-form);

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2386 mL	11.1929 mL	22.3859 mL	44.7718 mL
5mM	0.4477 mL	2.2386 mL	4.4772 mL	8.9544 mL
10mM	0.2239 mL	1.1193 mL	2.2386 mL	4.4772 mL
20mM	0.1119 mL	0.5596 mL	1.1193 mL	2.2386 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.