MC-Sq-Cit-PAB-Dolastatin10

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V32018 CAS #: 1941168-65-5 Purity ≥ 99%

Description: MC-Sq-Cit-PAB-Dolastatin10 is a bioreversible linkage and drug-linker conjugate used in the synthesis of ADC/antibody-drug conjugates. It employs Dolastatin10 (a tubulin polymerization inhibitor, anticancer agent and MMAE analog) linked via the ADC linker MC-Sq-Cit-PAB.

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Molecular Weight (MW)	1338.72
Molecular Formula	C₇₀H₁₀₅N₁₂O₁₂S
CAS No.	1941168-65-5

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.7470 mL	3.7349 mL	7.4698 mL	14.9396 mL
5mM	0.1494 mL	0.7470 mL	1.4940 mL	2.9879 mL
10mM	0.0747 mL	0.3735 mL	0.7470 mL	1.4940 mL
20mM	0.0373 mL	0.1867 mL	0.3735 mL	0.7470 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.