Ibrutinib dimer

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V39081 CAS #: 2031255-23-7 Purity ≥ 99%

Description: Ibrutinib dimer, the dimerized form of Ibrutinib, is an an impurity of Ibrutinib (PCI-32765; trade name Imbruvica) which is an irreversible and covalent Btk (Brutons tyrosine kinase) inhibitor that has been approved as an anticancer medication. Reference: Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

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Molecular Weight (MW)	880.99
Molecular Formula	C₅₀H₄₈N₁₂O₄
CAS No.	2031255-23-7
Synonyms	Ibrutinib dimer

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.1351 mL	5.6754 mL	11.3509 mL	22.7017 mL
5mM	0.2270 mL	1.1351 mL	2.2702 mL	4.5403 mL
10mM	0.1135 mL	0.5675 mL	1.1351 mL	2.2702 mL
20mM	0.0568 mL	0.2838 mL	0.5675 mL	1.1351 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.