Obatoclax | CAS 803712-67-6

Obatoclax

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Cat #: V39582 CAS #: 803712-67-6 Purity ≥ 99%

Description: Obatoclax (also known as GX-15070; GX15 070) is a potent pan-BCL-2 family proteins inhibitor with a Ki of 0.22 μM in a cell-free assay. Obatoclax binds to the BH3-binding site of BCL-2 and other related BCL-2 family members (including BCL-XL, MCL-1, A1, and BCL-B). As a pan-BCL-2 inhibitor, it is being investigated for the treatment of refractory malignancies, obatoclax mesylate directly induce apoptosis in cultured acute myeloid leukemia (AML) cells as well as primary patient samples and exhibits antitumor activity in mouse xengografts of solid tumor and myeloma cell lines. The Bcl-2 family of proteins are overexpressed in various cancers such as the lymphatic system, breast, lung, prostate, and colon. Therefore, Obatoclax has anticancer activity as an Bcl-2 inhibitor.

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Molecular Weight (MW)	317.38
Molecular Formula	C₂₀H₁₉N₃O
CAS No.	803712-67-6
SMILES Code	COC1=CC(C(N2)=CC3=C2C=CC=C3)=N/C1=CC4=C(C)C=C(C)N4
Synonyms	GX15-070; GX-05-070; GX 15-070; Obatoclax; GX05-070; GX 05-070

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1508 mL	15.7540 mL	31.5080 mL	63.0159 mL
5mM	0.6302 mL	3.1508 mL	6.3016 mL	12.6032 mL
10mM	0.3151 mL	1.5754 mL	3.1508 mL	6.3016 mL
20mM	0.1575 mL	0.7877 mL	1.5754 mL	3.1508 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.