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: Cat #: V38660 CAS #: 81093-43-8 Purity ≥ 99%
Description: 3α-Hydroxy pravastatin sodium is a major metabolite of the lipid-lowering drug Pravastatin. Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. It is natural product isolated from cultures of Nocardia autotrophica. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
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| Molecular Weight (MW) | 446.51 |
|---|---|
| Molecular Formula | C₂₃H₃₅NaO₇ |
| CAS No. | 81093-43-8 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2396 mL | 11.1980 mL | 22.3959 mL | 44.7918 mL |
| 5mM | 0.4479 mL | 2.2396 mL | 4.4792 mL | 8.9584 mL |
| 10mM | 0.2240 mL | 1.1198 mL | 2.2396 mL | 4.4792 mL |
| 20mM | 0.1120 mL | 0.5599 mL | 1.1198 mL | 2.2396 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.