NALDEMEDINE | CAS 916072-89-4

NALDEMEDINE

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V3923 CAS #: 916072-89-4 Purity ≥ 98%

Description: Naldemedine (formerly known as S-297,995; S297995; trade name: Symproic) is a potent, orally bioavailable peripherally active, and selective μ-opioid receptor antagonist developed by Shionogi and has been approved in 2017 for the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain. Clinical studies have thus far found it to possess statistically significant effectiveness for these indications and to be generally well-tolerated with predominantly mild to moderate gastrointestinal side effects. No effects indicative of central opioid withdrawal or impact on the analgesic or miotic effects of co-administered opioids have been observed.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	570.65
Molecular Formula	C32H34N4O6
CAS No.	916072-89-4
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
SMILES Code	O=C(C1=C(O)[C@@H]2[C@]34C5=C(O2)C(O)=CC=C5C[C@@H](N(CC6CC6)CC4)[C@]3(O)C1)NC(C)(C7=NC(C8=CC=CC=C8)=NO7)C
Synonyms	S-297,995; S297,995; S 297995; S-297995; S297995; S 297,995; trade name: Symproic

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7524 mL	8.7619 mL	17.5239 mL	35.0478 mL
5mM	0.3505 mL	1.7524 mL	3.5048 mL	7.0096 mL
10mM	0.1752 mL	0.8762 mL	1.7524 mL	3.5048 mL
20mM	0.0876 mL	0.4381 mL	0.8762 mL	1.7524 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.