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Tezosentan

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Tezosentan
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Cat #: V3655 CAS #: 180384-57-0 Purity ≥ 98%

Description: Tezosentan (RO610612; Veletr; RO-610612) is a novel, non-selective and dual antagonist/inhibitor of endothelian (ETA/ETB) receptor (pA2s of 9.5, 7.7 for ETA and ETB) with the potential to be used for the treatment of congestive heart failure. Tezosentan acts as a vasodilator and was designed as a therapy for patients with acute heart failure. Tezosentan inhibits uptake of proinflammatory endothelin-1 in stenotic aortic valves. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. Tezosentan reduces the renal injury induced by abdominal aortic ischemia-reperfusion in rats.

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CAS No.180384-57-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.