Fosnetupitant

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V3897 CAS #: 1703748-89-3 Purity ≥ 98%

Description: Fosnetupitant (07PNET; 07-PNET; Fosnetupitant chloride; Akynzeo), the prodrug of netupitant, is a novel and potent antagonist of neurokinin receptor used in combination with palonosetron to prevent nausea and vomiting caused by chemotherapy. Neurokinin 1 (NK1) receptor antagonists are a class of drug used to treat nausea and vomiting associated with chemotherapy. Aprepitant, casopitant, and fosaprepitant are NK1 drugs. As of April 2018, the combination of fosnetupitant and palonosetron has been approved by FDA to prevent acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	688.61
Molecular Formula	C31H35F6N4O5P
CAS No.	1703748-89-3
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
SMILES Code	CC1=CC=CC=C1C2=CC(N(CC3)CC[N+]3(C)COP([O-])(O)=O)=NC=C2N(C)C(C(C)(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)=O
Synonyms	07PNET; 07-PNET; Fosnetupitant chloride; Akynzeo; trade name: Akynzeo

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.4522 mL	7.2610 mL	14.5220 mL	29.0440 mL
5mM	0.2904 mL	1.4522 mL	2.9044 mL	5.8088 mL
10mM	0.1452 mL	0.7261 mL	1.4522 mL	2.9044 mL
20mM	0.0726 mL	0.3631 mL	0.7261 mL	1.4522 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.