MK-3328 | CAS 1201323-97-8

MK-3328

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Cat #: V4294 CAS #: 1201323-97-8 Purity ≥ 98%

Description: MK-3328 is a novel and potent candidate PET ligand for the clinical assessment of β-amyloid plaque load. As a β-Amyloid PET ligand, MK-3328 exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 has a favorable potency versus human β-amyloid plaque and has been radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. Studies led to the identification of 17b (MK-3328) as a candidate PET ligand for the clinical assessment of β-amyloid plaque load. MK-3328 is currently being tested for the treatment of Alzheimer's Disease.

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CAS No.	1201323-97-8
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent

Related Biological Data

(a) Autoradiographic images of AD human cortex after treatment with 5 nM [3H3]-labeled compound. (b) Autoradiographic images of AD human cortex after treatment with 5 nM [3H3]-labeled compound in the presence of 1 μM unlabeled compound (self-block). ACS Med Chem Lett. 2011 Apr 18;2(7):498-502.

(a) Decay corrected time−activity curves for [18F]17b in cortex (red circles), cerebellum (blue squares), and white-matter (black diamonds). (b) MRI coregistered rhesus PET image at 45−90 min with [18F]17b. Cerebellum was used as a baseline reference. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502.

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.