Pradefovir (Remofovir)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5mg	$420	To Be Confirmed
10mg	$750	To Be Confirmed
25mg	$1350	To Be Confirmed
50mg	$2150	To Be Confirmed

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Cat #: V3959 CAS #: 625095-60-5 Purity ≥ 98%

Description: Pradefovir (formerly known as Remofovir, ICN-2001-3, MB-06866, MB-6866; ICN-20013) is an RTI (reverse transcriptase) inhibitor that has the potential for the treatment of chronic HBV infection. Pradefovir is prodrug of adefovir that is designed to target liver. Pradefovir can be activated to PMEA (9-(2-phosphonylmethoxyethyl)adenine ) in human liver microsomes with with a Km of 60 μM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 ml/min.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	423.79
Molecular Formula	C17H19ClN5O4P
CAS No.	625095-60-5
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 50 mg/mL
	Water: N/A
	Ethanol: N/A
SMILES Code	ClC1=CC([C@H]2O[P@](OCC2)(COCCN3C=NC4=C(N)N=CN=C34)=O)=CC=C1
Synonyms	Remofovir; ICN-2001-3; MB-06866; MB 06866; MB06866; MB6866; MB-6866; MB 6866; ICN-20013; ICN20013; ICN2001-3;

Related Biological Data

Ketoconazole inhibition of conversion of pradefovir to PMEA in human liver microsomes as a percentage of the control activity (mean; n = 2) versus the concentration of pradefovir. Antimicrob Agents Chemother. 2006 Sep;50(9):2926-31.

Determination of Ki (slope versus [I] plot) for ketoconazole on conversion of pradefovir to PMEA (mean; n = 2). Antimicrob Agents Chemother. 2006 Sep;50(9):2926-31.

MAb 3A4 inhibition of conversion of pradefovir to PMEA (mean; n = 2) in human liver microsomes. Antimicrob Agents Chemother. 2006 Sep;50(9):2926-31.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3597 mL	11.7983 mL	23.5966 mL	47.1932 mL
5mM	0.4719 mL	2.3597 mL	4.7193 mL	9.4386 mL
10mM	0.2360 mL	1.1798 mL	2.3597 mL	4.7193 mL
20mM	0.1180 mL	0.5899 mL	1.1798 mL	2.3597 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.