CL-316243 disodium

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V18448 CAS #: 138908-40-4 Purity ≥ 99%

Description: CL-316243 disodium (CL316243) is a novel and potent β3-adrenoceptor agonist with the potential for the treatment obesity, diabetes and urge urinary incontinence. It activates β3-adrenoceptor with a EC50 of 3 nM.

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Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	465.7935
Molecular Formula	C20H18ClNNa2O7
CAS No.	138908-40-4
Synonyms	CL316243; CL 316243

Protocol	In Vitro	CL 316243 displays binding affinities with IC50 values of 0.6 μM and 1 μM for rat heart and rat soleus muscle respectively[1]. CL 316243 inhibits spontaneously contracting, isolated rat detrusor strips in a concentration dependent manner with a mean concentration inhibiting 50% of maximal response of 2.65 nM[3].
Protocol	In Vivo	CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 weeks) elevates the mRNA and protein expression levels of UCP1 in BAT, irrespective of diet[2]. Animal Model: Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks[2] Dosage: 0.1 mg/kg/day Administration: once a day; 1 weeks Result: Exhibited a premium effect of obesity in mice.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1469 mL	10.7344 mL	21.4687 mL	42.9375 mL
5mM	0.4294 mL	2.1469 mL	4.2937 mL	8.5875 mL
10mM	0.2147 mL	1.0734 mL	2.1469 mL	4.2937 mL
20mM	0.1073 mL	0.5367 mL	1.0734 mL	2.1469 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.