ML-290 | CAS 1482500-76-4

ML-290

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5mg	$200	To Be Confirmed
10mg	$350	To Be Confirmed
25mg	$550	To Be Confirmed
50mg	$950	To Be Confirmed
100mg	$1650	To Be Confirmed

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Cat #: V4015 CAS #: 1482500-76-4 Purity ≥ 98%

Description: ML-290, a 2-acetamido-N-phenylbenzamide analog, is a novel potent, selective and orally bioactive agonist of the relaxin/insulin-like family peptide receptor (RXFP1) and an activator of anti-fibrotic genes with an EC50 of 94 nM. It was identified from a dose responsive quantitative high throughput screen (qHTS) of >350,000 compounds against a human relaxin/insulin-like family peptide receptor (RXFP1) transfected HEK293 cell line. ML-290 has excellent in vivo PK properties with high levels of systemic exposure. ML-290 represents the first-in-class small-molecule agonists of RXFP1 and is a potent activator of anti-fibrotic genes.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	506.5
Molecular Formula	C24H21F3N2O5S
CAS No.	1482500-76-4
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10mM
	Water: N/A
	Ethanol: N/A
SMILES Code	O=C(NC1=CC=CC(S(=O)(C(F)(F)F)=O)=C1)C2=CC=CC=C2NC(C3=CC=CC=C3OC(C)C)=O
Synonyms	ML290; ML 290; ML-290

Related Biological Data

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9743 mL	9.8717 mL	19.7433 mL	39.4867 mL
5mM	0.3949 mL	1.9743 mL	3.9487 mL	7.8973 mL
10mM	0.1974 mL	0.9872 mL	1.9743 mL	3.9487 mL
20mM	0.0987 mL	0.4936 mL	0.9872 mL	1.9743 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.