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| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | 3-6 Days |
| 10mg | $100 | 3-6 Days |
| 25mg | $150 | 3-6 Days |
| 50mg | $245 | 3-6 Days |
| 100mg | $450 | 3-6 Days |
| 250mg | $850 | 3-6 Days |
| 500mg | $1450 | 3-6 Days |
: Cat #: V2109 CAS #: 1346528-06-0 Purity ≥ 98%
Description: ML241 is a novel and potent p97 inhibitor which inhibits p97 ATPase with an IC50 value of 100 nM. ML241 inhibited degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 also impaired the endoplasmic-reticulum-associated degradation (ERAD) pathway. The AAA ATPase p97 is a critical factor in maintaining protein homeostasis in eukaryotic cells, through its roles in promoting degradation of ubiquinated proteins by the proteasome and in maturation of autophagosomes. ML241 has the potential for treating cancer.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 372.46 |
|---|---|
| Molecular Formula | C23H24N4O |
| CAS No. | 1346528-06-0 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 30mg/mL |
| Water: N/A | |
| Ethanol: N/A | |
| SMILES Code | C1(N2CCOC3=CC=CC=C23)=NC(NCC4=CC=CC=C4)=C5CCCCC5=N1 |
| Synonyms | ML241; ML-241; ML 241 |
| Related Biological Data |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6849 mL | 13.4243 mL | 26.8485 mL | 53.6970 mL |
| 5mM | 0.5370 mL | 2.6849 mL | 5.3697 mL | 10.7394 mL |
| 10mM | 0.2685 mL | 1.3424 mL | 2.6849 mL | 5.3697 mL |
| 20mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 2.6849 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.