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Acipimox (K-9321)

This product is for research use only, not for human use. We do not sell to patients.

Acipimox (K-9321)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$603-6 Days
100mg$853-6 Days
250mg$1153-6 Days
500mg$1753-6 Days
1g$3003-6 Days
2g$4803-6 Days
5g$9003-6 Days

Cat #: V2086 CAS #: 51037-30-0 Purity ≥ 98%

Description: Acipimox (also known as Olbemox; K-9321; Olbetam) is a novel and potent niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout.

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Product Promise

Promise
Molecular Weight (MW)154.12
Molecular FormulaC6H6N2O3
CAS No.51037-30-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 31 mg/mL (201.1 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SynonymsOlbemox; K-9321; K9321; K 9321; Olbetam
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM6.4885 mL32.4423 mL64.8845 mL129.7690 mL
5mM1.2977 mL6.4885 mL12.9769 mL25.9538 mL
10mM0.6488 mL3.2442 mL6.4885 mL12.9769 mL
20mM0.3244 mL1.6221 mL3.2442 mL6.4885 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.