Clindamycin HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
5g	$800	Check With Us
10g	$1350	Check With Us
20g	$2025	Check With Us

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Cat #: V15477 CAS #: 21462-39-5 Purity ≥ 99%

Description: Clindamycin HCl (U-21251; Cleocin, U21251; Clinsol; EC 244-398-6; EC2443986; U 21251 F; Clinacin, Dalacin), the hydrochloride salt of Clindamycin which is a semisynthetic analog of lincomycin and ribosomal translocation / protein inhibitor, is a potent antibiotic acting as a protein synthesis inhibitor.

References: Batzias GC, et al. Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. Vet J. 2005 Nov; 170(3):339-45.

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Molecular Weight (MW)	461.439
Molecular Formula	C18H34Cl2N2O5S
CAS No.	21462-39-5
SMILES Code	CCC[C@@H]1C[C@@H](C(N[C@@H]([C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C)=O)N(C1)C.Cl
Synonyms	Cleocin; Cleocin HCl; U21251F; U-21251-F; Clinsol; EC 244-398-6; EC2443986; U 21251 F; U-21251; EC-244-398-6; U 21251; Clindamycin

Protocol	In Vivo	Clindamycin hydrochloride dogs have fast oral absorption, mean time to absorption (MAT) of 0.87 hours, and bioavailability of 72.55%. Clindamycin hydrochloride resulted in total clearance (CL) of Clindamycin (0.503 versus 0.458 L/h/kg) both intravenously and orally administered in dogs. The steady-state (IV) volume of distribution of Clindamycin hydrochloride is 2.48 L/kg, indicating that clindamycin is widely distributed in body fluids and tissues. Serum concentrations of Clindamycin hydrochloride are maintained above 0.5 micrograms/mL for approximately 10 hours after intravenous and oral administration

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1671 mL	10.8357 mL	21.6713 mL	43.3427 mL
5mM	0.4334 mL	2.1671 mL	4.3343 mL	8.6685 mL
10mM	0.2167 mL	1.0836 mL	2.1671 mL	4.3343 mL
20mM	0.1084 mL	0.5418 mL	1.0836 mL	2.1671 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.