Tigecycline
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $300 | In Stock |
| 500mg | $500 | In Stock |
| 1g | $750 | In Stock |
: Cat #: V5447 CAS #: 220620-09-7 Purity ≥ 98%
Description: Tigecycline (GAR936; GAR-936; TYGACL) is a potent tetracycline antibiotic which is bacteriostatic.
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| Molecular Weight (MW) | 585.65 |
|---|---|
| Molecular Formula | C29H39N5O8 |
| CAS No. | 220620-09-7 |
| Synonyms | GAR-936; GAR936; GAR936; TYGACL; Tigecycline |
| Protocol | In Vitro | Tigecycline (0.63-30 μM, pre-incubated for 4 days, treated for 72 h) inhibits AML2 cells and HL-60 cells, IC50 4.72±0.54 and 3.06±0.85 μM (freshly prepared), respectively. Tigecycline inhibits AML2 cells and HL-60 cells, IC50 5.64±0.55 and 4.27±0.45 μM, respectively (pre-incubation for 1 day). Tigecycline inhibits AML2 cells and HL-60 cells, IC50 5.02±0.60 and 4.39±0.44 μM, respectively (pre-incubation for 2 day). Tigecycline inhibits AML2 cells and HL-60 cells, IC50 4.09±0.41, and 3.95±0.39 μM, respectively (pre-incubation for 3 days). After 4 days of pre-incubation in saline, Tigecycline lost its ability to kill TEX human leukemia cells (from freshly prepared ICs50~5 μM 到 IC50>After 50 days of pre-incubation with 4 μM), measured by the CellTiter Flour assay |
|---|---|---|
| In Vivo | Peak plasma concentration (C.max), terminal half-life (t1/2), the clearance rate (CL) and volume of distribution (Vz) of Tigecycline in normal saline were 22.8 μg/mL, 108.9 min, 1912.2 min*μg/mL, 26.1 mL/min/kg, and 4109.4 mL/kg, respectively. Peak plasma concentration (C.max), terminal half-life (t1/2), area under the concentration-time curve (AUC), clearance (CL), and volume of distribution (Vz) of 15.7 μg/mL, 110.3 min, 2036.5 min*μg/mL, 24.6 mL/min/kg, 3906.2 mL/kg Tigecycline in the formulation (60 mg/mL pyruvate, 3 mg/mL ascorbic acid, pH 7 in normal saline) | |
| Animal model | NOD/SCID mice with OCI-AML2 acute myeloid leukemia (AML) xenograft model | |
| Dosages | 50 mg/kg | |
| Administration | Intraperitoneal injection; twice a day; for 11 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7075 mL | 8.5375 mL | 17.0750 mL | 34.1501 mL |
| 5mM | 0.3415 mL | 1.7075 mL | 3.4150 mL | 6.8300 mL |
| 10mM | 0.1708 mL | 0.8538 mL | 1.7075 mL | 3.4150 mL |
| 20mM | 0.0854 mL | 0.4269 mL | 0.8538 mL | 1.7075 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.