Trimethoprim (Trimpex)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100g | $450 | To Be Confirmed |
| 200g | $700 | To Be Confirmed |
| 500g | $1200 | To Be Confirmed |
: Cat #: V5172 CAS #: 738-70-5 Purity ≥ 98%
Description: Trimethoprim (TMP), an approved drug, is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of UTIs-urinary tract infectionssuch as bladder infections.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 290.32 |
|---|---|
| Molecular Formula | C14H18N4O3 |
| CAS No. | 738-70-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vivo | Trimethoprim (10 mg/kg； Intravenous injection; Every 12 hours; 3 days) showed antimicrobial activity against H. Protective effect of influenza bacteria, Streptococcus pneumoniae, Escherichia coli and meningococcal infection in mice |
|---|---|---|
| Animal model | Female C3H/HeOuJ mice (transurethrally infected with a 50 μL suspension containing 1-2×107 CFU of E. coli under 3% isoflurane) | |
| Dosages | 10 mg/kg | |
| Administration | i.v.; once every 12 h; for 3 d |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4445 mL | 17.2224 mL | 34.4448 mL | 68.8895 mL |
| 5mM | 0.6889 mL | 3.4445 mL | 6.8890 mL | 13.7779 mL |
| 10mM | 0.3444 mL | 1.7222 mL | 3.4445 mL | 6.8890 mL |
| 20mM | 0.1722 mL | 0.8611 mL | 1.7222 mL | 3.4445 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.