Dolutegravir (GSK1349572)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $300 | Check With Us |
| 500mg | $400 | Check With Us |
| 1g | $600 | Check With Us |
: Cat #: V1832 CAS #: 1051375-16-6 Purity ≥ 98%
Description: Dolutegravir (formerly also known as GSK1349572; GSK-1349572; Tivicay) is a novel, potent and orally bioavailable two-metal-binding HIV integrase inhibitor approved to treating HIV infections.
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| Molecular Weight (MW) | 419.38 |
|---|---|
| Molecular Formula | C20H19F2N3O5 |
| CAS No. | 1051375-16-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 83 mg/mL (197.9 mM)r |
| Water:<1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Synonyms | S/GSK1349572; GSK1349572; GSK-1349572; GSK 1349572. Tivicay; S/GSK-1349572; (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide |
| Protocol | In Vitro | The EC50 of Dolutegravir (S/GSK1349572) against HIV-1 is 0.51 nM in PBMCs, 0.71 nM in MT-4 cells, and 2.2 nM in the PHIV assay, which uses a pseudotyped self-inactivating virus. The 50% cytotoxic concentrations (CC50) for Dolutegravir in proliferating IM-9, U-937, MT-4, and Molt-4 cells are 4.8, 7.0, 14, and 15 μM, respectively. In unstimulated and stimulated PBMCs, the CC50 are 189 μM and 52 μM, respectively. Based on the EC50 of Dolutegravir against HIV-1 in PBMCs (i.e., 0.51 nM), this translates to a cell-based therapeutic index of at least 9,400 |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3845 mL | 11.9224 mL | 23.8447 mL | 47.6894 mL |
| 5mM | 0.4769 mL | 2.3845 mL | 4.7689 mL | 9.5379 mL |
| 10mM | 0.2384 mL | 1.1922 mL | 2.3845 mL | 4.7689 mL |
| 20mM | 0.1192 mL | 0.5961 mL | 1.1922 mL | 2.3845 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.