Dapivirine (TMC120)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$750	Check With Us
500mg	$1125	Check With Us
1g	$1685	Check With Us

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Cat #: V1827 CAS #: 244767-67-7 Purity ≥ 98%

Description: Dapivirine (also known as TMC120) is a potent non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, it inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.

References: Weiwen Liu, et al. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma. J Cancer. 2018 Jan 1;9(1):117-128.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	329.4
Molecular Formula	C20H19N5
CAS No.	244767-67-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 34 mg/mL (103.2 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	TMC120; TMC 120; TMC-120; R 147681; R-147681; R147681; Dapivirine.

Protocol	In Vitro	Dapivirine (4-64 μM, 24, 48, 72, 96 and 120 hours) inhibits proliferation of glioma cells and induces apoptosis (16 μM, 12-48 h)
	In Vivo	Dapivirine (16 mg/kg, once every 3 days for 12 days) exhibits potent antitumor activity in human glioblastoma models in mice
	Animal model	U87 cells were subcutaneously injected into the nude mice
	Dosages	16 mg/kg.
	Administration	Once every 3 days for 12 days.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0358 mL	15.1791 mL	30.3582 mL	60.7165 mL
5mM	0.6072 mL	3.0358 mL	6.0716 mL	12.1433 mL
10mM	0.3036 mL	1.5179 mL	3.0358 mL	6.0716 mL
20mM	0.1518 mL	0.7590 mL	1.5179 mL	3.0358 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.