Cabotegravir (GSK744; GSK1265744)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | In Stock |
| 500mg | $750 | In Stock |
| 1g | $1125 | In Stock |
: Cat #: V1835 CAS #: 1051375-10-0 Purity ≥ 98%
Description: Cabotegravir (formerly GSK744; GSK1265744; GSK-744; GSK-1265744; Rekambys; Cabenuva) is a potent, orally bioavailable and long-acting inhibitor of HIV integrase approved in 2020 for the treatment and prevention of HIV infection.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 405.35 |
|---|---|
| Molecular Formula | C19H17F2N3O5 |
| CAS No. | 1051375-10-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 38 mg/mL (93.7 mM)r |
| Water:<1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| SMILES Code | C[C@H]1CO[C@H]2N1C(C3=C(O)C(C(C(NCC4=C(F)C=C(F)C=C4)=O)=CN3C2)=O)=O |
| Synonyms | GSK744; S/GSK 1265744; GSK-744; S/GSK1265744; GSK 744; S/GSK-1265744; Cabotegravir; Cabenuva. Chemical Name: (3S,11aR)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide Exact Mass: 405.1136 |
| Protocol | In Vitro | Cabotegravir (GSK-1265744) Inhibits HIV-1 integrase-catalyzed chain transfer in vitro, IC50 is 3.0 nM. Antiviral EC against HIV-1 Ba-L in PBMCs50 EC of 0.22 nM to NL43250 is 0.34 nM. In MT-4 cells, EC measured with CellTiter-Glo50 EC measured for 0.57 nM, MTT50 1.3 nM EC in PHIV assay using pseudoautoinactivated virus50 is 0.5 nM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4670 mL | 12.3350 mL | 24.6700 mL | 49.3401 mL |
| 5mM | 0.4934 mL | 2.4670 mL | 4.9340 mL | 9.8680 mL |
| 10mM | 0.2467 mL | 1.2335 mL | 2.4670 mL | 4.9340 mL |
| 20mM | 0.1234 mL | 0.6168 mL | 1.2335 mL | 2.4670 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.