RS-504393
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $600 | Check With Us |
| 100mg | $990 | Check With Us |
| 200mg | $1485 | Check With Us |
: Cat #: V14057 CAS #: 300816-15-3 Purity ≥ 98%
Description: RS-504393 is a potent and highly selective CCR2 chemokine receptor antagonist with IC50s of 98 nM and > 100 µM for inhibition of human recombinant CCR2b and CCR1 receptors respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 417.50 |
|---|---|
| Molecular Formula | C25H27N3O3 |
| CAS No. | 300816-15-3 |
| SMILES Code | CC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C |
| Protocol | In Vitro | RS 504393 inhibits MCP-1-induced chemotaxis, IC50 is 330 nM. RS 504393 treatment significantly inhibits allergen-induced β-hexosamine release. In the absence of allergen initiation, MCP-1 induces mast cell degranulation, which is completely inhibited by RS 504393 |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3952 mL | 11.9760 mL | 23.9521 mL | 47.9042 mL |
| 5mM | 0.4790 mL | 2.3952 mL | 4.7904 mL | 9.5808 mL |
| 10mM | 0.2395 mL | 1.1976 mL | 2.3952 mL | 4.7904 mL |
| 20mM | 0.1198 mL | 0.5988 mL | 1.1976 mL | 2.3952 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.