Visnagin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $500 | To Be Confirmed |
| 2g | $750 | To Be Confirmed |
| 5g | $1265 | To Be Confirmed |
: Cat #: V34615 CAS #: 82-57-5 Purity ≥ 99%
Description: Visnagin is naturally occurring furanocoumarin isolated from A. visnaga with antioxidant, anti-inflammatory and analgesic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 230.22 |
|---|---|
| Molecular Formula | C13H10O4 |
| CAS No. | 82-57-5 |
| SMILES Code | O=C1C=C(OC2=C1C(OC)=C3C=COC3=C2)C |
| Synonyms | Visnagin; NSC 100593; NSC 100593; NSC 100593; |
| Protocol | In Vitro | Visnagin (10 µM; for 16 h) elevates CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner, whereas MNF (3’-methoxy-4’-nitroflavone; 20 µM; pre-treated for 1 h) successfully counteracted this induction. Visnagin also enhances PAI-2 transcription in an AHR-dependent manner. Visnagin (10 µM; for 4, 8, 16, 24 h) induces CYP1A1 transcription in HepG2 cells. |
|---|---|---|
| In Vivo | Visnagin dose dependently decreases the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuates the levels of nuclear p65-NFκB. Visnagin improves the antioxidant defence by improving Nrf2 expression and halts pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells. Visnagin (10, 30, 60 mg/kg; ip; for 7 days) is effective in reducing plasma amylase and lipase levels and reduces Cerulein (50 μg/kg, six, hourly i.p. injections) induced oxidative stress in male Swiss albino mice (age: 6-8 weeks, weighing 20-25 g). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3437 mL | 21.7184 mL | 43.4367 mL | 86.8734 mL |
| 5mM | 0.8687 mL | 4.3437 mL | 8.6873 mL | 17.3747 mL |
| 10mM | 0.4344 mL | 2.1718 mL | 4.3437 mL | 8.6873 mL |
| 20mM | 0.2172 mL | 1.0859 mL | 2.1718 mL | 4.3437 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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Volume(start)
V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.